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单 位: 成都大学新葡的京集团35222vip-Welcome
通讯地址: 成都市龙泉驿区成洛大道2205号成都大学高等研究院C301
电子邮件: diwulab@163.com
简 历
2020.06—至今,成都大学,新葡的京集团35222vip-Welcome,特聘研究员;
2017.07—2020.05,成都大学,新葡的京集团35222vip-Welcome,副研究员
2015.08—2016.09,加拿大多伦多大学,化学学院,访问学者
2012.09—2017.07,四川大学,化学工程学院,应用化学,工学博士(硕博连读)
2008.09—2012.07,四川大学,化学工程学院,制药工程,工学学士
主要研究方向
研究方向:食品化学,食品多组分互作,光调控蛋白质策略
主要科研
主要从事有机小分子与生物大分子互作的机理学研究及光调控蛋白质构象功能的应用策略技术。曾师从光调控蛋白质方向的权威科学家Andrew Woolley,系统细化了该领域涉及的知识与方法,并将该方向关键技术引进回国,突破了该光控技术难以在生物体中延长有效波段的技术瓶颈,并同我省高校及研究院所化学生物学领域的同行共享研究方法与光调控工艺的技术关键。近年来,主持国家自然科学基金青年基金1项,四川省科技厅应用基础面上项目1项,其它省部及厅局级项目4项,参与国家自科基金及四川省重大科技成果转化分析测试平台建设项目3项,累计可支配经费90余万。公开发表国内外学术论文90余篇,其中第一作者/通讯作者发表SCI论文50余篇(高被引论文3篇,中科院一区TOP论文20余篇),申报中国发明专利2项。担任Food Chemistry、Carbohydrate Polymers 、Food Hydrocolloids、Toxicology in Vitro、Food Bioscience、Luminescence等多个SCI期刊审稿人。承担《无机化学》、《食品分析》、《食品加工新技术研究进展》等课程的教学工作,指导大学生创新训练计划项目5项(国家级2项,省部级3项),指导学科竞赛获国家级、省部级奖多项,获拔尖创新人才培养荣誉学业导师称号,参编专著1部。已培养硕士研究生14人。近五年参加国际及全国性学术会议近10次,作国际会议学术汇报2次。
主要科研项目
1. 国家自科基金青年基金项目:基于红光驱动的偶氮苯衍生物分子开关光调控蛋溶菌酶构象的研究(21808020,30万,2019-2021),主持
2. 四川省科技厅科技计划应用基础面上项目:基于偶氮类食品着色剂光调控α-螺旋多肽构象的可行性研究及其应用(2018JY0151,10万,2018-2019),主持
3. 北京市食品添加剂工程技术研究中心开放基金:基于偶氮色素光控多肽片段(2019年,4.5万,2019-2020),主持
4. 农业部杂粮加工重点实验室开放基金:藜麦皂苷与功能性蛋白质的相互作用机制研究及功效评价(2018CC16,2万,2019-2020),主持
5. 肉类加工四川省重点实验室开放基金:肉制品防腐剂叔丁基羟基茴香醚及其代谢产物与血清白蛋白的相互作用研究(19-R-01,2019-2020)
6. 高层次人才培育经费,2020-2025,50万,主持
7. 校人才引进启动项目,2017—2020,30万,主持。
科研成果
1.Di Wu*, Ran Duan, Lang Tang, Xia Hu, Fang Geng, Qiaomei Sun, Yin Zhang, Hui Li. Binding mechanism and functional evaluation of quercetin 3-rhamnoside on lipase, Food Chemistry, 2021, 359:129960.
2.Di Wu*, Ran Duan, Lan Tang, Dian Zhou, Zhen Zeng, Wen Wu, Jie Hu, Qiaomei Sun.In-vitro binding analysis and inhibitory effect of capsaicin on lipase, LWT-food science and technology ,2022, 154.
3.Di Wu*,Lan Tang,Ran Duan,Xia Hu,Fang Geng,Yin Zhang,Lianxin Peng, Hui Li.Interaction mechanisms and structure-affinity relationships between hyperoside and soybean β-conglycinin and glycinin, Food Chemistry, 2021,347:129052.
4.Ran Duan, Di Wu*,Lan Tang, Xia Hu, Lei Cheng, Hongqin Yang, Han mei Li, Fang Geng.Interactions of thecisandtransstates of an azobenzene photoswitch with lysozyme induced by red and blue light, Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy, 2020, 229: 117965.
5.Lan Tang,Jie Hu,Sen Mei, Di Wu*,Jing Zhang,Wen Wu,Hanmei Li,Hui Li. Comparative analysis of the interaction between azobenzene di-maleimide and human serum albumin/lysozyme, Journal of Molecular Structure,2022,1252.
6.Di Wu*,Sen Mei,Ran Duan,Fang Geng,Wanxia Wu,Xiang Li,Lei Cheng,Chengtao Wang. How black tea pigment theaflavin dyes chicken eggs: Binding affinity study of theaflavin with ovalbumin, Food Chemistry, 2020, 303:125407.
7.Di Wu, Mingxin Dong, Catherine V. Collins, Amirhossein Babalhavaeji,G. Andrew Woolley.A Red-Light Azobenzene Di-Maleimide Photoswitch: Pros and Cons Advanced, Optical Materials, 2016, 4(9): 1402-9
8.Di Wu*, Jinqiu Wang, Dayu Liu, Yin Zhang, Xia Hu. Computational and spectroscopic analysis of interaction between food colorant citrus red 2 and human serum albumin, Scientific Reports,2019,9(1):1615.
9.Di Wu*, Ran Duan, Fang Geng, Xia Hu, Na Gan, Hui Li.Comparative analysis of the interaction of mono-, dis-, and tris-azo food dyes with egg white lysozyme: A combined spectroscopic and computational simulation approach, Food Chemistry, 2019, 284: 180-7.
10.Di Wu*,Dayu Liu,Yin Zhang,Zhen Zhang,Hui Li. Unravelling the binding mechanism of benproperine with human serum albumin: A docking,fluorometric, and thermodynamic approach, European Journal of Medicinal Chemistry,2018, 146: 245-50.
11.Xia Hu, Di Wu*, Lan Tang, Jing Zhang, Zhen Zeng, Fang Geng, Hui Li. Binding mechanism and antioxidant activity of piperine to hemoglobin, Food Chemistry, 2022, 394:133558.
12. Di Wu*, Wen Wu, Lan Tang, Xia Hu, Jing Zhang, Hanmei Li, Hui Li. Simulation-guided relationships and interaction characteristics of human CtBP1 in complex with protocatechualdehyde, Journal of Molecular Liquids, 2022, 360:119507.
13.Di Wu*, Lan Tang, Zhen Zeng, Jing Zhang, Xia Hu, Qingqing Pan, Fang Geng, Hui Li. Analytical delivery of hyperoside by using a soybean protein isolated-soy soluble polysaccharide nanocomplex: Fabrication, characterization, and in vitro release properties, Food Chemistry, 2022, 386:132837.
14.Jie Hu, Di Wu*, Qingqing Pan, Hanmei Li, Jing Zhang, Fang Geng. Recent Development of Photoresponsive Liposomes Based on Organic Photosensitizers, Au Nanoparticles, and Azobenzene Derivatives for Nanomedicine, ACS Applied Nano Materials, 2022, 5(10), 14171–14190.
15. Xia Hu, Zhen Zeng, Jing Zhang, Di Wu*, Hui Li, Fang Geng. Molecular dynamics simulation of the interaction of food proteins with small molecules[J]. Food Chemistry, 2023, 405:134824.
16. Wen Wu, Xia Hu, Zhen Zeng, Di Wu*, Hanmei Li, Hui Li. Characterization of the Binding Properties of Sorafenib to c-MYC G-Quadruplexes: Evidence for Screening Potential Ligands[J]. The Journal of Physical Chemistry B, 2023, 127(4): 874-883.
17. Zhen Zeng, Di Wu*, Lan Tang, Xia Hu, Jing Zhang, Fang Geng. Exploring the binding effects and inhibiting mechanism of hyperoside to lipase using multi-spectroscopic approaches, isothermal titration calorimetry, inhibition kinetics and molecular dynamics[J]. RSC Advances, 2023, 13: 6507.