郝理

作者:时间:23-03-07 10:37浏览:字体:


单位:成都大学新葡的京集团35222vip-Welcome

通讯地址:成都市成洛大道2025成都大学新葡的京集团35222vip-Welcome9D203

电子邮件:haoli@cdu.edu.cn


20136月本科毕业于西南大学园艺园林学院园艺专业,获农学学士学位

20156月硕士毕业于中国农业大学农学与生物技术学院园艺专业,获农业推广硕士学位

20207月博士毕业于中国农业大学园艺学院果树学专业,获农学博士学位

20209—20229月于电子科技大学基础与前沿研究院生物物理学博士后

202210至今于成都大学新葡的京集团35222vip-Welcome任讲师。


主要研究方向

主要利用生物信息学、分子生物学知识、基因工程、转基因手段、荧光显微镜等,挖掘并验证非生物胁迫相关基因的功能,进行药用植物分子育种筛选和种质创新。


主要科研和教学

作为研究骨干参加多项国家自然科学基金面上项目、国家重点研发计划、国家梨产业技术体系等项目。共发表论文10余篇以及授权国家发明专利4项。


主要科研项目

1. 成都大学校人才启动项目(2081923037),负责,铁皮石斛糖转运蛋白参与非生物胁迫的分子机制及其利用,2022/12-2026/12

2. 国家自然科学基金(面上项目),参与,真核生物转录耦合DNA修复机制的单分子水平研究,2023/1-2026/1

3. 四川省自然科学基金(面上项目),参与,基于单分子生物技术的EGFR突变与非小细胞肺癌演进的可视化研究,2023-01-012024-12-31


科研成果(近五年)

1. Zhang Y*, Hao L*, Wang N, Bai X, Zhang Y. Transcriptome-wide identification and expression profiling of SWEET family in Bletilla striata and regulation analysis with non-coding RNAs. Industrial Crops and Products. 2023, 201:116876. (1TOP, IF= 5.9)

2. Zhai F*, Hao L*, Chen X, Jiang T, Guo Q, Xie L, Ma Y, Du X, Zheng Z, Chen K, Fan J. Single-molecule tracking of PprI in D. radiodurans without interference of autoblinking. Frontiers in Microbiology. 2023, 14:1256711. (2TOPIF=5.2)

3. Hao L, Shi X, Qin S, Dong J, Shi H, Wang Y, Zhang Y. Genome-wide identification, characterization and transcriptional profile of SWEET gene family in Dendrobium officinale. BMC Genomics. 2023, 24:378. (2TOP, IF= 4.4)

4. Hao L*, Wang S*, Zhang Y, Xu C, Yu Y, Xiang L, Huang W, Tian B, Li T, Wang S. Long-distance transport of the pear HMGR1 mRNA via the phloem is associated with enhanced salt tolerance. Plant Science. 2023, 332:111705. (2, IF=5.2)

5. Hao L, Zhang Y. Genome-wide analysis of miR159 gene family and predicted target genes associated with environmental stress in Dendrobium officinale: A bioinformatics study. Genes (Basel). 2022, 13(7):1221. (IF= 4.141)

6. Hao L, Zhang Y, Wang S, Zhang W, Wang S, Xu C, Yu Y, Li T, Jiang F, Li W. A constitutive and drought-responsive mRNA undergoes long-distance transport in pear (Pyrus betulaefolia) phloem. Plant Science. 2020, 293:110419. (2, IF= 5.363)

7. 郝理, 江婷, 樊军. RNA聚合酶动态调控DNA转录的单分子水平研究进展[J]. 自然杂志, 2022, doi: 10.3969/j.issn.0253-9608.2022.05.010.

8. Wang S, Duan X, Wang S, Hao L, Zhang Y, Xu C, Yu Y, Xiang L, Jiang F, Heinlein M, Li T, Zhang W. A chaperonin containing T-complex polypeptide-1 facilitates the formation of the PbWoxT1-PbPTB3 ribonucleoprotein complex for long-distance RNA trafficking in Pyrus betulaefolia. New Phytologist. 2023. doi: 10.1111/nph.18789. (IF= 10.323)

9. Zhang Y*, Wang S*, Li W, Wang S, Hao L, Xu C, Yu Y, Xiang L, Li T. A long noncoding RNA HILinc1 enhances pear thermotolerance by stabilizing PbHILT1 transcripts through complementary base pairing. Communications Biology. 2022, 5:1134. (IF= 6.548)

10. Ma L*, Zeng Q*, Huang W*, Wang S, Zhang Y, Cheng Y, Zhang Q, Wang S, Hao L, Xu C, Yu Y, Wang B, Li T, Jiang F. Incidence of major pome fruit tree viruses and viroids in commercial pear orchards in China and in Pyrus betulifolia seedlings. Plant Pathology. 2021, 00:1-9.

11. Zhang Y, Zhang Q, Hao L, Wang S, Wang S, Zhang W, Xu C, Yu Y, Li T. A novel miRNA negatively regulates resistance to Glomerella leaf spot by suppressing expression of an NBS gene in apple. Horticulture research. 2019, 6:93. (IF= 7.291)

12. Wang S, Wang S, Zhang W, Zhang Q, Hao L, Zhang Y, Xu C,Yu Y,Wang B,Li T, Jiang F. PbTTG1 forms a ribonucleoprotein complex with polypyrimidine tract-binding protein PbPTB3 to facilitate the long-distance trafficking of PbWoxT1 mRNA. Plant Science. 2019, 280:424-432. (IF= 5.363)

13. Zhang Q, Zhang Y, Wang S, Hao L, Wang S, Xu C, Jiang F, Li T. Characterization of genome‑wide microRNAs and their roles in development and biotic stress in pear. Planta. 2018, 249(3):693-707. (IF= 4.540)

14. Zhang Q, Ma C, Zhang Y, Gu Z, Li W, Duan X, Wang S, Hao L, Wang Y, Wang S, Li T. A Single-Nucleotide Polymorphism in the Promoter of a Hairpin RNA Contributes to Alternaria alternata Leaf Spot Resistance in Apple (Malus × domestica). The Plant Cell, 2018, 30(8):1924-1942. (IF= 12.085)

15. 李天忠,郝理,王胜男,王圣元. 一种砧木改良方法及其应用. 中国专利, ZL202011436357.6, 2021-11-23

16. 李天忠,郝理,王胜男,王圣元. 一种HMGR基因mRNA在梨属砧穗间传递的分子鉴定方法. 中国专利, ZL201610390843.6, 2020-07-28

17. 李天忠,郝理,王胜男,王圣元,徐超然. 一种FT mRNA分子在同属植物砧穗间传递的分子鉴定方法. 中国专利, ZL201810445842.6, 2020-06-16

18. 李天忠,郝理,王胜男,王圣元,陈佳琪. 一种mRNA分子在植物砧穗间传递的荧光鉴定方法. 中国专利, ZL201710040058.2, 2020-04-10